- Phone : +1 (416) 978-4539
- Email : brenda.coles@utoronto.ca
- Address : 160 College Street, 11th floor Donnelly Centre
for Cellular and Biomolecular
Research University of Toronto
VDK
Lab
Neurobiology
Research Group
Welcome to the Neurobiology Research Group. We are made up of a collaboration of projects in the van der Kooy lab. These projects are divided into 3 main areas of interest:
2024 Publications
Maal-Bared, G., Yee, M., Harding, E. K., Ghebreselassie, M., Bergamini, M., Choy, R., Kim, E., Di Vito, S., Patel, M., Amirzadeh, M., Grieder, T. E., Coles, B. L., Nagy, J. I., Bonin, R. P., Steenland, H. W., & D.van der Kooy (2024).
2023 Publications
Vargas-Perez H, Grieder T, van der Kooy D (van der Kooy’s h-index 104). (2023). Neural plasticity in theventral tegmental area, aversive motivation during drug withdrawal and hallucinogenic therapy.

2022 Publications
Merritt DM, MacKay-Clackett I, Almeida SMT, Tran C, Ansar S, van der Kooy D. (2022). Arrestin-mediated Desensitization Enables Olfactory Discrimination in C. elegans. PNAS. 119(31): e2116957119.http://dx.doi.org/doi:10.1073/pnas.2116957119
Core Academic & Knowledge
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College Advisory
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Curriculum & Pedagogy
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Latest News
Areas of Research

About VDK
Derek van der Kooy received a M.Sc. in Psychology at the University of British Columbia, and a Ph.D in Anatomy, first at Erasmus University in the Netherlands, and finishing in the Department of Anatomy at the University of Toronto. Dr. van der Kooy gained postdoctoral research experience at Cambridge University in England and at the Salk Institute in California. In 1981, Derek became an Assistant Professor at the University of Toronto, was promoted to Associate Professor in 1986, then served as Professor in the Department of Anatomy and Cell Biology at the University of Toronto from 1991- 2002, and has since become a Professor in the Department of Molecular Genetics.
To The Journey Ahead
Gain Valuable Knowledge & Experience
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You Apply
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We Connect
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We Are Open For Opportunities!
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VDK Lab
Learning and Memory Genes
A mutational analysis has begun to reveal the component processes of learning and memory. We have developed associative (classical conditioning) and non-associative (habituation) learning paradigms using olfactory and taste stimuli in the best understood multicellular organism, the worm C. elegans. Mutational screens in progress have identified new genes which code for critical components of associative (lrn-1 and lrn-2) and non-associative (adp-1) learning. These new genes reveal the separable neuronal and molecular stubstrates underlying associative learning and habituation.
Graduate On Time
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Students Skill
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Campus Extracurricular
87%
Quality Of Lecturers
92%
spread over 25 cities in 9 regions
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interested in joining us ?
Neurobiology of Motivation
Our primary objective is to characterize the neurobiological substrates of motivation. Our overall hypothesis is that separate, double dissociable, neural mechanisms underlie the rewarding effects of opiates in drug naive versus drug-dependent and deprived animals. Lesions of the tegmental pedunculopontine nucleus (TPP) block the conditioned place preferences produced by morphine in drug naive rats, but not in opiate dependent and deprived rats. Dopamine antagonists block the conditioned place preferences produced by morphine in opiate dependent and deprived rats, but not in drug naive rats.
Our Team
People
Testimonials

Lab Technician / Manager
Retinal Stem Cell Biology and Lab Management

PhD Candidate
Neural Crest Reprogramming and Retinal Biology

Consultant
Optogenetics and Electrophysiology

Consultant
Using optogenetic techniques to investigate the motivation of opiate reward

Research Volunteer
Corneal Stem Cell Biology